β2-Adrenergic Receptor Thr164Ile Polymorphism, Obesity, and Diabetes: Comparison withFTO,MC4R, andTMEM18Polymorphisms in More Than 64,000 Individuals
نویسندگان
چکیده
منابع مشابه
Arginine 16 Glycine Polymorphism in β2-Adrenergic Receptor Gene is Associated with Obesity, Hyperlipidemia, Hyperleptinemia, and Insulin Resistance in Saudis
Background. Several studies have shown an association between codon 16 polymorphism of the β2AR gene and obesity. Methods. We studied the association between Arg16Gly polymorphism and obesity and its influence on anthropometric parameters, lipids, insulin resistance and leptin in Saudi individuals. The study group included 329 individuals (males: 109 and females: 220). Metabolic parameters, inc...
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Background: Genetic polymorphism is responsible for variations and individual differences. Polymorphism is a major factor of complex diseases with unknown etiology and cancer. Inconsistency in the symptoms of polycystic ovary syndrome (monthly disorder, hirsutism, obesity, diabetes, infertility) is one of the major pathological complications of this syndrome. The present study was conducted to ...
متن کاملassociation between β2-adrenergic receptor-16arg/gly gene polymorphism and chronic obstructive pulmonary disease risk:systematic review and meta-analysis.
the association between β2-adrenergic receptor (adrb2) -16arg/gly polymorphism (rs1042713) and chronic obstructive pulmonary disease (copd) risk has been investigated in many published studies. however, the results were inconclusive. a meta-analysis was performed to make a more precise estimation of the relationship.the pubmed, embase, isi web of science, the cochrane database of systematic rev...
متن کاملActivation mechanism of the β2-adrenergic receptor.
A third of marketed drugs act by binding to a G-protein-coupled receptor (GPCR) and either triggering or preventing receptor activation. Although recent crystal structures have provided snapshots of both active and inactive functional states of GPCRs, these structures do not reveal the mechanism by which GPCRs transition between these states. Here we propose an activation mechanism for the β(2)...
متن کاملEffect of β2-Adrenergic Receptor Polymorphism in Asthma Control of Patients Receiving Combination Treatment
PURPOSE Combination treatment of inhaled corticosteroid (ICS) plus long-acting beta2-agonist (LABA) is widely used as a maintenance regimen for the management of asthma. This study evaluated the effect of the beta2-adrenergic receptor (ADRB2) polymorphism on lung function and asthma control with regular use of combination treatment of an inhaled ICS plus LABA. MATERIALS AND METHODS 43 Korean ...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2012
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2011-3282